Twice now while playing DK1 my mouse pointer will abruptly start to scroll all the way to the left side of the screen and keep on going non stop until I get to the other end of the map. Then, it'll get "stuck" there. I can't bring up the menu or restart the game. I can only alt tab out of the program, shut it down and restart it. Has this happened to anyone else? Does anyone know how to fix it? I don't think it's an issue with my house as when I alt tab to Windows my mouse cursor moves around just fine.

Thanks!

Yeah it's an annoying bug, but I think you can still save and close the game with keyboard commands when it happens:
https://www.gog.com/forum/dungeon_keeper_series/dungeon_keeper_1_the_mouse_keeps_moving_to_the_left